Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antiviralsby Tricot et al.
The authors of this study demonstrate that both human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) and the Huh7 hepatoma cell line support the complete ZIKV replication cycle.
The authors of this study found that Culex quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. These mosquitoes are therefore very unlikely to play a role in transmission of ZIKV.
Results from this study suggest that ZIKV has mechanisms to evade mosquito innate immunity and it is therefore important to understand virus-vector interactions and the implications they have on transmission.