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Leiden University Medical Center

PARTNER N°	5
NAME OF INSTITUTION	Leiden University Medical Center
BRIEF DESCRIPTION OF THE TEAM
	Leiden University Medical Center, department of Medical Microbiology The LUMC (7000 employees, >700 million turnover) is an internationally renowned biomedical research institute. The Molecular Virology team, headed by Prof. Eric Snijder, is among the world leaders in studying the molecular biology of +RNA virus replication and virus-host interactions (over 200 papers published) and uses this knowledge to develop novel antiviral strategies, with a special focus on corona-, alpha-, and flaviviruses, including ZIKV. There is extensive experience in development of research tools for various +RNA viruses, including virus culture, reverse genetics technology, biosafe systems (replicons), biochemical assays, protein-RNA interaction studies, advanced light and electron microscopy, functional genomics (siRNA, shRNA, CRISPR/Cas) and proteomics screening of infected cells. The Department is fully equipped for molecular virological, biochemical and antiviral studies, and includes several BSL-2 labs and a state-of-the-art BSL-3 facility with the possibility to use radioactive isotopes (for MoA studies) and automation for medium-throughput screens. The diagnostics section and collaboration with the Department of Infectious Disease (special interest in travel-related infections) provides access to a large collection of clinical samples, including panels of control sera. The group of prof. Gorbalenya has state-of-the-art bioinformatics facilities, including in-house developed software platforms (e.g. VIRALIS) for virus bioinformatics studies.
KEY CONTACT PERSON(S)
Key scientific contact person 1 (Team leader)
Name	Dr. Martijn van Hemert
Photo
Position in the Institution	Principal Investigator
Email address	M.J.van_Hemert@lumc.nl
Phone number	+31 71 5266793
Mobile phone number
Postal address	Dr. M.J. van Hemert Department of Medical Microbiology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden The Netherlands
Role in the Consortium	WP3 (co-leader)
	Task: 1, 3, & 4
	Sub-task: 1.1, 1.2, 1.3, 3.1, 3.2, 3.3 & 4.3
	Role: WP3 co-leader ; Task 1 leader ; Subtask 1.2 leader ; Task 1.1, 1.2, 1.3, 3.1, 3.2, 3.3, and 4.3 contributor Analysis of the mechanisms of infection and characterization of the replication cycle of ZIKV in cell culture, including the identification of host factors involved in ZIKV infection and elucidation of their role in replication. Development of a ZIKV tool box aimed at providing ZIKV-specific assays, materials, protocols etc to other tasks and WPs, e.g. to support development of diagnostics or perform mode-of-action studies on antiviral compounds. This includes reverse genetics systems (including biosafe systems and reporter viruses), cell culture models and panels of ZIKV isolates. Molecular virological studies to elucidate the mode of action of compounds with anti-ZIKV activity identified by other partners within WP3.