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Institut Pasteur Paris

PARTNER N°	8a
NAME OF INSTITUTION	Institut Pasteur
BRIEF DESCRIPTION OF THE TEAM
	The objectives of our laboratory are to evaluate the relative contributions of genetic and environmental factors in the transmission of arboviruses by insect vectors. To do this, we examine the vectorial system under different angles: (1) viral diversity generated by passing in mosquitoes and (2) role of mosquito anatomical filters (midgut and salivary glands) in selecting variants, (3) environmental influences such as the role of microbial fauna and temperature on transmission. We utilize several virus/mosquito models: dengue, Chikungunya, Rift Valley fever, West-Nile, Yellow fever, Zika.
KEY CONTACT PERSON(S)
Key scientific contact person 1 (Team leader)
Name	Failloux Anna-Bella
Photo
Position in the Institution	Directeur de Recherche Head of the unit “Arboviruses and Insect Vectors”
Email address	anna-bella.failloux@pasteur.fr
Phone number	+33(0)140613617
Mobile phone number	+33(0)786603527
Postal address	25 rue du Dr Roux 75724 Paris cedex 15 France
Role in the Consortium	WP: leader of WP6
	Task: co-leader of Task 6.3
	Sub-task:
	WP6 aims to apprehend the transmission of Zika virus through the angle of the mosquito vector. Our strategy will be based on: (1) the identification of vectors involved in ZIKV transmission, (2) the assessment of vector competence of different mosquito (wild and domestic) populations, (3) the understanding of interactions between ZIKV and other flaviviruses with potential consequences in selecting new epidemic variants of ZIKV, (4) interactions of Zika virus with vectors/vector cells, and (5) the appraisal of insecticide resistance and design of alternative strategies for the control of disease transmission. WP6 will be developed under four 4 tasks. My laboratory will be more specifically involved as co-leader in task 6.3 on co-infections as driver of viral selection (ZIKV-DENV, ZIKV-CHIKV). The presence of different arboviruses cohabiting in the vector may modify the composition of each viral population. This could result in rapid viral genetic evolution, potentially leading to changes in the infectivity or pathogenicity of viruses.