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PARTNER N° |
1a |
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NAME OF INSTITUTION |
Inserm |
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BRIEF DESCRIPTION OF THE TEAM |
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The unit (Unité des Virus Emergents) is specialized in the study of emerging viral pathogens with a specific focus on arboviruses. The investigation fields include diagnosis (French National Reference Centre for Arboviruses), epidemiology, genomics and evolution, reverse genetics, antiviral therapy and all ecological and medical aspects of the natural history of viral infection. |
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KEY CONTACT PERSON(S) |
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Key scientific contact person 1 (Team leader) |
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Name |
Xavier de Lamballerie |
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Photo |
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Position in the Institution |
Professor, head of the unit |
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Email address |
xavier.de-lamballerie@univ-amu.fr |
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Phone number
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+33 4 91 32 44 20 |
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Mobile phone number |
+ 33 6 40 60 89 40 |
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Postal address |
Unité des virus Emergents UMR IRD 190 – Inserm 1207 Faculté de Médecine 27 Bd J Moulin 13005 Marseille France |
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Role in the Consortium |
ZIKAlliance coordinator |
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WP1 |
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Task 1.4 : Epidemiology Subtask 1.4.1: Seroprevalence studies Subtask 1.4.2: Blood donors |
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WP2 |
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Task 2.1 : Establishment of laboratory support of cohort studies Subtask 2.1.1: Definition and follow-up of procedures and diagnostic algorithms Subtask 2.1.2: Preparation & coordination of the different laboratory sites Subtask 2.1.3: Genomic Data pooling platform and governance Subtask 2.1.4: Development of high throughput surrogate assays to measure ZIKV neutralizing antibodies |
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Task 2.2: Description of natural history of infection & impact of previous flaviviral exposure Subtask 2.2.1: Determination of kinetics of viral shedding and antibody response Subtask 2.2.3: Virus analysis by whole genome amplicon based sequencing in different body fluids Subtask 2.2.4. Metagenomic analysis of viromes of patients with ZIKV virus infection with and without complications |
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WP3 |
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Task 3.2 : Comparative genomics Subtask 3.2.2: Virus genetic diversity and genetic epidemiology (virulence/emergence) Subtask 3.2.3: Molecular epidemiology & phylogeography |
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Task 3.3 : Development of a ZIKV toolbox Subtask 3.3.1: Reverse genetics & development of biosafe reporter systems Subtask 3.3.2: ZIKV-specific assays and reagents, including panel of clinical isolates and relevant cell culture systems |
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Task 3.4 : Antivirals Subtask 3.4.1: Compound library screening & repurposing of inhibitors Subtask 3.4.3: Activity against clinical isolates & Mechanism of Action studies Subtask 3.4.4: Efficacy of selected antiviral compounds in animal models for ZIKV infection |
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WP5 |
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Task 5.3: In vitro studies to determine the tropism, susceptibility and innate immune responses induced by ZIKV and related flaviviruses Subtask 5.3.3. Comparative flavivirus tropism |
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WP6 |
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Task 6.3: Interactions between ZIKV and other flaviviruses Subtask 6.3.1: Co-infections as driver of viral selection |
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WP7 |
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Task 7.3: Beliefs and behaviors related to risk of Zika infection |
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WP9 |
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Task 9.1: Contract and finance management |
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Task 9.2: Strategic steering |
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Task 9.3: Periodic reporting |
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Task 9.4: Organisation of ZIKAlliance Executive Committee meetings |
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Task 9.5 Exploitation of project results, intellectual property and sustainability |
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WP10 |
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Task 10.1: Harmonization of protocols and standardization of data capture tools Subtask 10.1.2: Standardization of data capture and data management Task 10.2.: To set up joint harmonized platforms for clinical research Subtask 10.2.1: To set up a reciprocal clinical monitoring platform Subtask 10.2.2: To set up a joint laboratory diagnostics EQA platform Subtask 10.2.3 To set up a joint virtual biobanking platform Subtask 10.2.4 Establishing principles of governance for the joint virtual biobanking platform |
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WP11 |
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Task 11.1: Setting-up common bodies for the global management of the scientific programmes Sub-Task 11.1.1: Creating a common Scientific Advisory Board Sub-Task 11.1.2: Setting-up an external Ethics Advisory Committee |
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Task 11.3: Organising integrated communication Sub-Task 11.3.1: Creating a Communication Oversight Board and Communication Harmonization Plan Sub-Task 11.3.2: Organizing joint meetings and representation of all consortia in relevant project specific meetings |
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Task 11.4: Organising Cross-Consortia working groups |
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WP12 (co-PI) |
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Task 12.1: Creating core preparedness structures |
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Task 12.2: Capacity building SubTask 12.2.1: Educational activity review and development SubTask 12.2.2: Training for the reciprocal clinical monitoring network SubTask 12.2.3: Training for the laboratory diagnostics EQA platform |
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