Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals
by Tricot et al.The authors of this study demonstrate that both human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) and the Huh7 hepatoma cell line support the complete ZIKV replication cycle.
19th December 2018 •
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Culex quinquefasciatus mosquitoes do not support replication of Zika virus
by Lourenço-de-Oliveira et al.The authors of this study found that Culex quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. These mosquitoes are therefore very unlikely to play a role in transmission of ZIKV.
27th October 2017 •
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Characterization of the Zika virus induced small RNA response in Aedes aegypti cells
by Varjak et al.Results from this study suggest that ZIKV has mechanisms to evade mosquito innate immunity and it is therefore important to understand virus-vector interactions and the implications they have on transmission.
23rd October 2017 •
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