The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa
by Ayres et al.These results suggest that populations carrying the same kdr mutations may respond differently to the same insecticide, stressing the need for complementary studies when assessing the impact of kdr resistance mechanisms in the outcome of insecticide-based control strategies.
Enhanced Molecular Surveillance of Chikungunya Virus
by Fischer et al.The authors of this study developed two highly sensitive nested RT-PCR assays that cover hot spots of vector adaptation in CHIKV envelope domains. The new assays allow unprecedented molecular surveillance across all CHIKV genotypes and diagnostic use in resource-limited settings globally.
Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases
by Selisko et al.In this article, the authors review current knowledge on motifs A-G, defined as the conserved amino-acid sequence strings shared by enzymes, and their role on the structural and mechanistic basis of the fidelity of nucleotide selection and RNA synthesis by Flavivirus RdRps.