A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein
by Qu et al.Results showed in this article have strong implications for developing anti-ZIKV vaccines and therapeutic mAbs.
Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji
by Henderson et al.Data from this study suggest that immunity against the Zika virus may not last as long as previously thought, which could affect the chances of future outbreaks.
High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel
by Denis et al.Researchers developed a ZEDIII-based ELISA that can discriminate between past or current DENV and ZIKV infections, allowing the detection of a serological scar from other flaviviruses. This could be used to confirm exposure of pregnant women or to follow the spread of an endemic disease.
Complex Scenario of Homotypic and Heterotypic Zika Virus Immune Enhancement
by Marques & DrexlerLetter to the Editor
The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis
by Langerak et al.In this review, the authors summarize the results of the evidence to date and elaborate on other possible detrimental effects of cross-reactive flavivirus antibodies, both for ZIKV infection and the risk of ZIKV-related congenital anomalies, DENV infection, and dengue hemorrhagic fever.
Zika Virus Seroprevalence in Urban and Rural Areas of Suriname, 2017
by Langerak et al.In Suriname, 770 participants were recruited from 1 urban area and 2 rural villages in the tropical rainforest in order to conduct a ZIKV serosurvey. Researchers found that 35.1% of the participants had neutralizing antibodies against ZIKV. In 1 remote village in the rainforest, 24.5% of the participants had neutralizing antibodies against ZIKV, suggesting that ZIKV was widely spread across the country.
Zika virus displacement by a chikungunya outbreak in Recife, Brazil
by Magalhaes et al.In 2015–2016 in the Recife Metropolitan Region, the authors of this study detected the tail end of a Zika epidemic, which was displaced by a chikungunya epidemic. Few dengue cases were identified despite a high number of official dengue notifications in the area during this period. This study shows here important epidemiological features of these cases.