Detection of arboviruses in mosquitoes: Evidence of circulation of chikungunya virus in Iran
by Bakhshi et al.This is the first report of mosquitoes infected with CHIKV in Iran. The high-throughput screening method here presented can be proposed as a novel epidemiological surveillance tool to identify circulating arboviruses and to support preparedness to an epidemic in animals and humans.
Estimating the risk of arbovirus transmission in Southern Europe using vector competence data
by Mariconti et al.Based on vector competence data and vector distribution, the auhtors generate a prediction risk map for CHIKV stressing the fear of CHIKV and to a lesser extent, of other arboviruses for Europe, calling us for new public health strategies.
High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel
by Denis et al.Researchers developed a ZEDIII-based ELISA that can discriminate between past or current DENV and ZIKV infections, allowing the detection of a serological scar from other flaviviruses. This could be used to confirm exposure of pregnant women or to follow the spread of an endemic disease.
Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil
by Pedroso et al.The results reported in this study suggest that multitypic dengue virus infection may protect from, rather than enhance, development of congenital Zika syndrome.
Phylogeography and invasion history of Aedes aegypti, the Dengue and Zika mosquito vector in Cape Verde islands (West Africa)
by Salgueiro et al.The authors of this study performed a phylogeographic and population genetics study of A. aegypti in Cape Verde in order to infer the geographic origin and evolutionary history of this mosquito.
This study shows a broad picture of possible interactions between mosquito cellular miRNAs and the viral RNA of different genotypes/lineages of arboviruses, providing a list of mosquito cellular miRNAs candidates for experimental validations in future studies.
Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus
by Kraemer et al.This study offers an opportunity to strategically target surveillance and control programmes and thereby augment efforts to reduce arbovirus burden in human populations globally.
The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis
by Langerak et al.In this review, the authors summarize the results of the evidence to date and elaborate on other possible detrimental effects of cross-reactive flavivirus antibodies, both for ZIKV infection and the risk of ZIKV-related congenital anomalies, DENV infection, and dengue hemorrhagic fever.
Results obtained in this study suggest that the local transmission of four arboviruses - dengue (DENV), chikungunya (CHIKV), zika (ZIKV) and yellow fever (YFV) viruses - by Ae. albopictus newly introduced in Morocco is a likely scenario.
Monocyte-Derived Dendritic Cells as Model to Evaluate Species Tropism of Mosquito-Borne Flaviviruses
by García-Nicolás et al.The authors of this study demonstrate Flavivirus-dependent differences in the interaction with monocyte-derived dendritic cells. These may play a role in pathogenesis but appear to only partially reflect the expected species tropism.
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors
by Hernandez et al.A fragment-based drug design approach on flavivirus methyltransferase.
Researchers report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes.
Estimating the risk of Dengue, Chikungunya and Zika outbreaks in a large European city
by Solimini et al.The model provided in this study correctly estimates the number of imported cases and can be easily adapted to other urban areas where Ae. albopictus is the only potential vector present.
Zika virus epidemiology in Bolivia: A seroprevalence study in volunteer blood donors
by Saba Villarroel et al.The authors conclude that ZIKV has been circulating in Bolivian tropical areas but not in highlands, and that the epidemic has not been limited by previous immunity against dengue. Specific attention should be paid to the region of Santa Cruz, where the seroprevalence is still limited, but the density of Aedes aegypti populations makes plausible further spreading of the disease.
Zika virus displacement by a chikungunya outbreak in Recife, Brazil
by Magalhaes et al.In 2015–2016 in the Recife Metropolitan Region, the authors of this study detected the tail end of a Zika epidemic, which was displaced by a chikungunya epidemic. Few dengue cases were identified despite a high number of official dengue notifications in the area during this period. This study shows here important epidemiological features of these cases.
Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence
by van Meer et al.Researchers have demonstrated that the recent ZIKV outbreak in Latin America substantially affects the DENV serology in routine diagnostic laboratories.
Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus
by Vicente-Santos et al.Results from this study indicate that bats do not sustain sufficient virus amplification in order to function as reservoirs and exclude them as players in the dengue virus transmission cycle.
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues
by Potisopon et al.In addition to representing the first ZIKV full-length NS5 activity report at the molecular level, this study should help the design of pan-flavivirus drugs aiming at the control of many Flavivirus members of this large family of emerging arboviruses, as well as understand the basis of re-purposing drugs against emerging viral diseases.
Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning
by Wolf et al.The article concludes that infection with Flaviviridae can increase centrosome numbers and impair spindle positioning, thus potentially contributing to microcephaly in the case of Zika.