Uncertainty in times of medical emergency: Knowledge gaps and structural ignorance during the Brazilian Zika crisisby Kelly et al.
Uncertainty was a defining feature of the Brazilian Zika crisis of 2015–2016. This article identifies three forms of uncertainty: global health, public health and clinical uncertainty, and it suggests that “emergency research” was effective in tackling global health uncertainty.
Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infectionby Alves et al.
This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies.
This pioneering study suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.
This study highlights the dual role of Axl during ZIKV infection of glial cells: promoting viral entry and modulating innate immune responses. Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies.
By using the bacterium-free ‘Infectious Subgenomic Amplicons’ (ISA) method, this study provides the scientific community with two simple and performing reverse genetics systems for ZIKV.