Our results show that both Ae. albopictus and Ae. aegypti, from Reunion Island, are more likely to be competent for ZIKV in contrast to Cx. quinquefasciatus which appeared refractory to all tested ZIKV strains. This improves our understanding of the role of mosquito species in the risk of the ZIKV emergence on Reunion Island.

6th August 2020 • comment

In this study, researchers provide the first demonstration of ZIKV accumulation in the saliva of Cx. pipiens upon forced infection. Nevertheless, they consider Cx. pipiens as a highly inefficient vector for ZIKV.

19th June 2020 • comment

Researchers have found that ZIKV immunity might be shorter-lived than previously thought, which may contribute to local ZIKV resurgence once individual immune responses wane sufficiently to reduce community protective immunity in addition to birth and migration.

15th June 2020 • comment

The present study showed that there is no evidence that the ZIKV established an independent sylvatic cycle in the state of Rio de Janeiro, and provided new evidence that there was no urban transmission of Yellow Fever Virus in southeast Brazil during the current outbreak.

26th March 2020 • comment

Findings from this article explain why explosive ZIKV epidemics occurred in DENV-endemic regions of Micronesia, Polynesia and the Americas where Culex-borne flavivirus outbreaks are infrequent, and why ZIKV did not cause major epidemics in Asia where Culex-borne flaviviruses are widespread.

1st February 2020 • comment


1st January 2020 • comment

Researchers developed a ZEDIII-based ELISA that can discriminate between past or current DENV and ZIKV infections, allowing the detection of a serological scar from other flaviviruses. This could be used to confirm exposure of pregnant women or to follow the spread of an endemic disease.

20th September 2019 • comment

Results from this research show that the differentiation state of hNPCs is a significant factor contributing to the outcome of ZIKV infection and furthermore suggest that ZIKV infection might initiate early activation of the Notch pathway resulting in an abnormal differentiation process, implicated in ZIKV-induced brain injury.

8th July 2019 • comment

Data in this study suggest that the human upper respiratory tract epithelium is a target for flaviviruses and could potentially play a role in the spread of infection to other body compartments through basolateral virus release. Further work is required to evaluate the risks and define the adapted measures to protect individuals exposed to flavivirus-contaminated body fluids.

16th April 2019 • comment

A fragment-based drug design approach on flavivirus methyltransferase.

1st January 2019 • comment

This study shows that treatment of mice with favipiravir (150 mg/kg/dose, BID, oral gavage) significantly reduced viral load in blood and tissues and significantly delayed virus-induced disease. The USUV mouse model is amenable for assessing the potential in vivo efficacy of (novel) USUV/flavivirus inhibitors.

13th November 2018 • comment

Since December 2016, Brazil has experienced an unusually large outbreak of yellow fever (YF). Whether urb a n transmission may contribute to the extent of the outbreak is unclear. The objective of this study was to characterize YF virus (YFV) genomes and to identify spatial patterns to determine thedistribution and origin of YF cases in Minas Gerais, Espírito Santo and Rio de Janeiro, the most affected Brazilian states during the current YFV outbreak.

7th February 2018 • comment

In this study researchers show that ZIKV containing BeH819015 structural proteins is much less efficient in cell-attachment leading to a reduced susceptibility ofepithelial A549 and neuronal SH-SY5Y cells to viral infection.

1st February 2018 • comment

The authors of this study tested nonhuman primates (NHP) sampled during 2012 to 2017 in urban and peri-urban areas severely affected by ZIKV and CHIKV in Brazil. Seroprevalence and antibody titers were low for both viruses. Additionally, they found evidence for infection by heterologous viruses eliciting cross-reactive antibodies. These data suggest that urban or peri-urban NHP are not easily infected by ZIKV and CHIKV despite intense local transmission, and they may also imply that the ZIKV and CHIKV outbreaks in the Americas cannot be sustained in urban or peri-urban NHP once human population immunity limits urban transmission cycles.

31st January 2018 • comment

In this article, the authors review current knowledge on motifs A-G, defined as the conserved amino-acid sequence strings shared by enzymes, and their role on the structural and mechanistic basis of the fidelity of nucleotide selection and RNA synthesis by Flavivirus RdRps.

30th January 2018 • comment

In addition to representing the first ZIKV full-length NS5 activity report at the molecular level, this study should help the design of pan-flavivirus drugs aiming at the control of many Flavivirus members of this large family of emerging arboviruses, as well as understand the basis of re-purposing drugs against emerging viral diseases.

21st February 2017 • comment

The results outlined in the article contribute to a better understanding of the ZIKVMTase, a central player in viral replication and host innate immune response, and lay the basis for the development of potential antiviral drugs.

21st February 2017 • comment